Evaluation of atopy in patients with COPD*

نویسندگان

  • Margarida Célia Lima Costa Neves
  • Yuri Costa Sarno Neves
  • Carlos Mauricio Cardeal Mendes
  • Monalisa Nobre Bastos
  • Aquiles Assunção Camelier
  • Cleriston Farias Queiroz
  • Bernardo Fonseca Mendoza
  • Antônio Carlos Moreira Lemos
  • Argemiro D'Oliveira Junior
چکیده

OBJECTIVE To determine the prevalence of atopy and to evaluate clinical, laboratory, and radiological profiles in patients with COPD. METHODS This was a cross-sectional study involving outpatients with stable COPD (defined by the clinical history and a post-bronchodilator FEV1/FVC < 70% of the predicted value). The patients completed a questionnaire regarding clinical characteristics and atopy, after which they underwent nasal lavage cytology, skin prick testing, chest X-rays, arterial blood gas analyses, and determination of total serum IgE. RESULTS Of the 149 subjects studied, 53 (35.6%), 49 (32.8%), and 88 (59.1%) presented with nasal eosinophilia, a positive skin prick test result, and symptoms of allergic rhinitis, respectively. Correspondence analysis confirmed these findings, showing two distinct patterns of disease expression: atopy in patients with COPD that was less severe; and no evidence of atopy in those with COPD that was more severe (reduced FEV1 and hyperinflation). There was a statistically significant association between nasal eosinophilia and a positive bronchodilator response. CONCLUSIONS Using simple and reproducible methods, we were able to show that there is a high frequency of atopy in patients with COPD. Monitoring inflammation in the upper airways can be a useful tool for evaluating respiratory diseases in the elderly and in those with concomitant asthma and COPD, a clinical entity not yet fully understood.

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عنوان ژورنال:

دوره 39  شماره 

صفحات  -

تاریخ انتشار 2013